Inhibition of β-hematin formation of Colombian species of Piper spp. and Calophyllum spp. as potential antimalarial agents.

 

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Detalles Bibliográficos
Autores: Mesa, Ana M., Blair, Silvia, Peláez, Carlos
Formato: artículo original
Estado:Versión publicada
Fecha de Publicación:2018
Descripción:New antimalarial agents from plants are studied as alternatives in the treatment of malaria. The main antimalarials such as chloroquine have several mechanisms of action against parasites, one of which is the inhibition of polymerization of the heme group, a model that has allowed the design of new antimalarial candidates. In this sense the objective of this work was to evaluate extracts of genus Piper and Calophyllum plants on the inhibition capacity of β-hematin. Inhibitory concentrations of β-hematin are reported from 40 extracts of different polarity obtained from the species P. piedecuestanum, C. brasiliense, C. longinforium, and Calophyllum. sp. 19 extracts showed a greater potential to inhibit β-hematin with IC50 > 3 mg/ml. These activities mainly support future studies with the genus Calophyllum in the development and discovery of new antiplasmodial substances with known modes of action.
País:Portal de Revistas UCR
Institución:Universidad de Costa Rica
Repositorio:Portal de Revistas UCR
Lenguaje:Español
OAI Identifier:oai:portal.ucr.ac.cr:article/32121
Acceso en línea:https://revistas.ucr.ac.cr/index.php/rbt/article/view/32121
Access Level:acceso abierto
Palabra clave:antiplasmodial
chloroquine
extracts
polymerization
heme group
cloroquina
extractos
polimerización
grupo hemo.