Comparison of biochemical and cytotoxic activities of extracts obtained from dorsal spines and caudal fin of adult and juvenile non-native Caribbean lionfish (Pterois volitans/miles)

 

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Detalles Bibliográficos
Autores: Ortiz Chaves, Natalia, Lomonte, Bruno, Rucavado Romero, Alexandra, Díaz Oreiro, Cecilia, Sáenz Espinoza, Aránzazu
Formato: artículo original
Fecha de Publicación:2017
Descripción:Pterois volitans/miles lionfish (adult and juvenile) dorsal spines and caudal fin extracts were compared in their general composition, enzymatic activities and hemolytic and cytotoxic effects on bovine aortic endothelial cells and murine myoblasts, to distinguish between the activities present in the venom and epidermal mucus. Intradermal and intramuscular injections were also administered in mice to determine in vivo effects. This work shows that crude venom of Caribbean species of lionfish, present in dorsal spines, induces several in vitro effects including hemolysis, weak cytotoxicity, proteolytic and hyaluronidase activities, whereas in vivo, it is not hemorrhagic nor myotoxic, but causes edema, plasma extravasation and a thrombotic-associated lesion on the skin. Some small differences were observed between adult and juvenile venomous secretions. Gelatinolytic activity of the epidermal mucus, the only activity found in caudal fin extracts, could contribute to the in vivo toxicity of the venom.
País:Kérwá
Institución:Universidad de Costa Rica
Repositorio:Kérwá
OAI Identifier:oai:https://www.kerwa.ucr.ac.cr:10669/74785
Acceso en línea:https://www.sciencedirect.com/science/article/pii/S0041010117302404?via%3Dihub
https://hdl.handle.net/10669/74785
Access Level:acceso abierto
Palabra clave:fish venom
lionfish
crude venom
Hemolysis
Cytotoxicity
Thrombosis
571.95 Toxicología