Bioactivity of prenylated hydroxybenzoic acids from Piper garagaranum C. DC
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| Autores: | , , , |
|---|---|
| Formato: | artículo original |
| Fecha de Publicación: | 2022 |
| Descripción: | A bio-assay guided fractionation of Piper garagaranum C. DC. led to the isolation of two prenylated hydroxybenzoic acids (1-2) with anti-inflammatory and cytotoxic activities. The anti-inflammatory action was determined in an LPS stimulated RAW 264.7 murine macrophage assay with IC50 values for inhibition of NO production of (18 ± 3) and (26 ± 5) μM, for 1 and 2, respectively. These compounds do not inhibit NO production by a competitive inhibition of the iNOS enzyme and show anti-inflammatory properties by lowering the expression of pro-inflammatory genes (TNF-α, IL-1β, CXCL2 and CCL2), as determined by qRT-PCR. Electrochemical measurements using cyclic voltammetry (CV) show that compound 1 exhibits anti-oxidant properties. This is the first phytochemical study of this plant, and we report a preliminary study of the biological activity of the isolated compounds. |
| País: | Kérwá |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:https://www.kerwa.ucr.ac.cr:10669/86998 |
| Acceso en línea: | https://www.sciencedirect.com/science/article/pii/S1874390021002421?via%3Dihub https://hdl.handle.net/10669/86998 |
| Access Level: | acceso abierto |
| Palabra clave: | Piper garagaranum C. DC. Anti-inflammatory Citotoxicity Gene expression Bio-assay guided fractionation Prenylated hydroxybenzoic acid |