Vismodegib and Hedgehog signalling pathway
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| Authors: | , |
|---|---|
| Format: | artículo original |
| Status: | Versión publicada |
| Publication Date: | 2015 |
| Description: | Sonic Hedgehog signaling pathway was discovered in the nineties, especially for its implication in the development of the embryo, which led to further investigations of its molecular biology. It promotes cell division and proliferation, and its role in oncogenesis was later described, especially in the basal cell carcinoma. The development of molecules to block this pathway, in order to treat this neoplasm, came into the creation of Vismodegib, a hedgehog pathway inhibitor which proof efficacy in the treatment of metastatic and locally advanced basal cell carcinoma. Research of this pathway and its clinical implications is continuous. |
| Country: | Portal de Revistas UCR |
| Institution: | Universidad de Costa Rica |
| Repositorio: | Portal de Revistas UCR |
| Language: | Español |
| OAI Identifier: | oai:portal.ucr.ac.cr:article/19642 |
| Online Access: | https://revistas.ucr.ac.cr/index.php/medica/article/view/19642 |
| Keyword: | proteínas sonic hedgehog neoplasias carcinoma basocelular vismodegib sonic hedgehog proteins neoplasm basal cell carcinoma |