The effect of solution environment and the electrostatic factor on the crystallisation of desmotropes of irbesartan

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Autores:	Araya, Andrea, Urgelles, Mariola, Vásquez Castro, Felipe, Vargas-Huertas, Felipe, Jose-Roberto, Vega-Baudrit, Guillen-Girón, Teodolito, Navarro-Hoyos, Mirtha, Cuffini, Silvia Lucia
Formato:	artículo
Fecha de Publicación:	2019
Descripción:	The experimental conditions necessary for stabilising irbesartan (IBS) tautomers in solution and selectively obtaining the desmotropic crystal forms are presented herein. 1H and 2H tautomers were stabilized in specific solution conditions and the 2H-tetrazole/imidazole interaction was confirmed by solution-state NMR. The results showed that highly polar and polarisable solvents (higher values of the electrostatic factor (EF)) lead to the crystallisation of IBS form B. Furthermore, the variations of pH in methanol, in turn, determined the crystallisation of desmotropes A and/or B
País:	Repositorio UNA
Institución:	Universidad Nacional de Costa Rica
Repositorio:	Repositorio UNA
Lenguaje:	Inglés
OAI Identifier:	oai:https://repositorio.una.ac.cr:11056/22338
Acceso en línea:	http://hdl.handle.net/11056/22338
Access Level:	acceso abierto
Palabra clave:	IRBESARTAN DESMOTROPIC FORMS TAUTOMERISM CRISTALIZACIÓN CRYSTALLIZATION