Inhibition of β-hematin formation of Colombian species of Piper spp. and Calophyllum spp. as potential antimalarial agents.

 

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون: Mesa, Ana M., Blair, Silvia, Peláez, Carlos
التنسيق: artículo original
الحالة:Versión publicada
تاريخ النشر:2018
الوصف:New antimalarial agents from plants are studied as alternatives in the treatment of malaria. The main antimalarials such as chloroquine have several mechanisms of action against parasites, one of which is the inhibition of polymerization of the heme group, a model that has allowed the design of new antimalarial candidates. In this sense the objective of this work was to evaluate extracts of genus Piper and Calophyllum plants on the inhibition capacity of β-hematin. Inhibitory concentrations of β-hematin are reported from 40 extracts of different polarity obtained from the species P. piedecuestanum, C. brasiliense, C. longinforium, and Calophyllum. sp. 19 extracts showed a greater potential to inhibit β-hematin with IC50 > 3 mg/ml. These activities mainly support future studies with the genus Calophyllum in the development and discovery of new antiplasmodial substances with known modes of action.
البلد:Portal de Revistas UCR
المؤسسة:Universidad de Costa Rica
Repositorio:Portal de Revistas UCR
اللغة:Español
OAI Identifier:oai:portal.ucr.ac.cr:article/32121
الوصول للمادة أونلاين:https://revistas.ucr.ac.cr/index.php/rbt/article/view/32121
Access Level:acceso abierto
كلمة مفتاحية:antiplasmodial
chloroquine
extracts
polymerization
heme group
cloroquina
extractos
polimerización
grupo hemo.