The membrane origin of epileptic‑related paroxysms: numerical experiments to model the transition from a pacemaker potential to paroxysmal depolarization shifts in the absence of synaptic inputs
সংরক্ষণ করুন:
| লেখক: | , |
|---|---|
| বিন্যাস: | artículo de revisión |
| প্রকাশনার তারিখ: | 2025 |
| বিবরন: | Paroxysmal depolarization shift (PDS) has been widely recognized as a characteristic feature of epileptic activity. The PDS is typically interpreted as a giant excitatory potential resulting from enhanced synaptic transmission, aligning with the prevailing understanding of epilepsy as a network mechanism that involves alterations in the balance of synaptic activity towards increased excitation. Several papers reported PDS recordings from single-cell snail neurons, and it has been hypothesized that PDS originates from abnormal pacemaker potentials. A physiologically inspired mathematical model was used to assess this hypothesis and examine the transition from a pacemaker potential to a PDS. By modifying several parameters in a first oscillation model, we demonstrated that it is possible to transition from fast, low-amplitude oscillations to slow, high-amplitude oscillations. Additionally, by smoothly adjusting specific biophysical parameters of the model, we could generate, long-lasting depolarizations resembling PDS in a bifurcation-like scenario. Notably, adding to this simplified model a spike-generating mechanism, former membrane biophysical changes evoked transitions from action potentials to doublets and PDS of increasing duration, as observed in single-cell recordings during dug-induced epileptic-like activity. Overall, our numerical experiments support the concept of pacemaker potential transitioning into the electrical characteristics of epileptic-like activity and suggest a potential scenario for this transition in the absence of synaptic inputs. |
| দেশ: | Kérwá |
| প্রতিষ্ঠান: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| ভাষা: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/101803 |
| অনলাইন ব্যবহার করুন: | https://hdl.handle.net/10669/101803 https://doi.org/10.1007/s12551-025-01284-z |
| মুখ্য শব্দ: | epilepsy paroxysm PDS invertebrate neuron mathematical modeling pacemaker potential |