Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction
Đã lưu trong:
| Nhiều tác giả: | , , , |
|---|---|
| Định dạng: | artículo original |
| Ngày xuất bản: | 2006 |
| Miêu tả: | ontext The association between coffee intake and risk of myocardial infarction (MI) remains controversial. Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. Individuals who are homozygous for the CYP1A2*1A allele are “rapid” caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are “slow” caffeine metabolizers. Objective To determine whether CYP1A2 genotype modifies the association between coffee consumption and risk of acute nonfatal MI. Design, Setting, and Participants Cases (n = 2014) with a first acute nonfatal MI and population-based controls (n = 2014) living in Costa Rica between 1994 and 2004, matched for age, sex, and area of residence, were genotyped by restriction fragment–length polymorphism polymerase chain reaction. A food frequency questionnaire was used to assess the intake of caffeinated coffee. |
| Quốc gia: | Kérwá |
| Tổ chức giáo dục: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Ngôn ngữ: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/83488 |
| Truy cập trực tuyến: | https://jamanetwork.com/journals/jama/fullarticle/202502?resultClick=1 https://hdl.handle.net/10669/83488 |
| Từ khóa: | Salud Infarto de miocardio Café |