Third-generation antivenomics analysis of the preclinical efficacy of Bothrofav® antivenom towards Bothrops lanceolatus venom
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| Autoři: | , , , , , |
|---|---|
| Médium: | artículo original |
| Datum vydání: | 2019 |
| Popis: | Bothrops lanceolatus inflicts severe envenomings in the Lesser Caribbean island of Martinique. Bothrofav®, a monospecific antivenom against B. lanceolatus venom, has proven highly effective at the preclinical and clinical levels. Here, we report a detailed third-generation antivenomics quantitative analysis of Bothrofav®. With the exception of poorly-immunogenic peptides, Bothrofav® immunocaptured all the major protein components. These results, along with previous preclinical and clinical observations, underscore the high neutralizing efficacy of the antivenom against B. lanceolatus venom. |
| Země: | Kérwá |
| Instituce: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Jazyk: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/103165 |
| On-line přístup: | https://hdl.handle.net/10669/103165 https://doi.org/10.1016/j.toxcx.2018.100004 |
| Klíčové slovo: | Bothrops lanceolatus Antivenom Snake venom Bothrofav® Third-generation antivenomics Martinique |