Hemorrhagic and procoagulant P-III snake venom metalloproteinases differ in their binding to the microvasculature of mouse cremaster muscle
में बचाया:
| लेखकों: | , , , |
|---|---|
| स्वरूप: | artículo original |
| प्रकाशन तिथि: | 2020 |
| विवरण: | Binding of two P-III snake venom metalloproteinase (SVMPs), one procoagulant and one hemorrhagic, to microvessels was compared in an ex vivo model. The procoagulant SVMP did not bind to the microvasculature, in contrast to the clear localization on microvessels of the hemorrhagic SVMP. Deglycosylation of the procoagulant enzyme did not enable this toxin to bind to microvessels, suggesting that glycosylation is not interfering with binding. These observations suggest that procoagulant SVMPs lack exosites for interaction with microvessels components. |
| देश: | Kérwá |
| संस्थान: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| भाषा: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/104174 |
| ऑनलाइन पहुंच: | https://hdl.handle.net/10669/104174 https://doi.org/10.1016/j.toxicon.2020.02.011 |
| संकेत शब्द: | snake venom metallopoteinases (SVMPs) hemorrhagic enzymes procoagulant enzymes glycosylation microvasculature confocal microscopy |