Hemorrhagic and procoagulant P-III snake venom metalloproteinases differ in their binding to the microvasculature of mouse cremaster muscle

保存先:

書誌詳細
著者:	Herrera Arias, Cristina, Escalante Muñoz, Teresa, Rucavado Romero, Alexandra, Gutiérrez, José María
フォーマット:	artículo original
出版日付:	2020
その他の書誌記述:	Binding of two P-III snake venom metalloproteinase (SVMPs), one procoagulant and one hemorrhagic, to microvessels was compared in an ex vivo model. The procoagulant SVMP did not bind to the microvasculature, in contrast to the clear localization on microvessels of the hemorrhagic SVMP. Deglycosylation of the procoagulant enzyme did not enable this toxin to bind to microvessels, suggesting that glycosylation is not interfering with binding. These observations suggest that procoagulant SVMPs lack exosites for interaction with microvessels components.
国:	Kérwá
機関:	Universidad de Costa Rica
Repositorio:	Kérwá
言語:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/104174
オンライン･アクセス:	https://hdl.handle.net/10669/104174 https://doi.org/10.1016/j.toxicon.2020.02.011
キーワード:	snake venom metallopoteinases (SVMPs) hemorrhagic enzymes procoagulant enzymes glycosylation microvasculature confocal microscopy