Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction
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| Autori: | , , |
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| Natura: | artículo original |
| Data di pubblicazione: | 2004 |
| Descrizione: | There is growing evidence that DNA damage caused by mutagens found in tobacco smoke may contribute to the development of coronary heart disease (CHD). In order to bind to DNA many mutagens require metabolic activation by cytochrome P450 (CYP) 1A1 or CYP1A2. The objective of this study was to determine the effects of CYP1A1 and CYP1A2 genotypes on risk of myocardial infarction (MI) and whether smoking interacts with genotype to modify risk. |
| Stato: | Kérwá |
| Istituzione: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/81247 |
| Accesso online: | https://jmg.bmj.com/content/41/10/758 https://hdl.handle.net/10669/81247 |
| Keyword: | Tabaco infarto de miocardio enfermedad coronaria |