Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom
保存先:
| 著者: | , , , , |
|---|---|
| フォーマット: | artículo original |
| 出版日付: | 2006 |
| その他の書誌記述: | Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 A ° resolution and the anion-binding site has been characterized. |
| 国: | Kérwá |
| 機関: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/74162 |
| オンライン･アクセス: | http://scripts.iucr.org/cgi-bin/paper?S1744309106010700 https://hdl.handle.net/10669/74162 |
| キーワード: | myotoxin Snake venom Lys49 phospholipase A2 anion-binding sites |