Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity.

 

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Detaylı Bibliyografya
Yazarlar: Dec, Eric, Clement, James, Cheng, Kaiyang, Church, George M., Fossel, Michael B., Rehkopf, David H., Rosero Bixby, Luis, Kobor, Michael S., Lin, David TS., Lu, Ake T., Fei, Zhe, Guo, Wei, Chew, Yap Ching, Yang, Xiaojing, Dwi Putra, Sulistyo E., Reiner, Alex P., Correa, Adolfo, Vilalta, Adrian, Pirazzini, Chiara, Passarino, Giuseppe, Monti, Daniela, Arosio, Beatrice, Garagnani, Paolo, Franceschi, Claudio, Horvath, Steve
Materyal Türü: artículo original
Yayın Tarihi:2023
Diğer Bilgiler:Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than 40, including n = 184 samples from centenarians, 122 samples from semi-supercentenarians (aged 105 +), and 25 samples from supercentenarians (aged 110 +). The oldest individual was 115 years old. Our most accurate centenarian clock resulted from applying a neural network model to a training set composed of individuals older than 40. An epigenome- wide association study of age in different age groups revealed that age effects in young individuals (age < 40) are correlated (r = 0.55) with age effects in old individuals (age > 90). We present a chromatin state analysis of age effects in centenarians. The centenarian clocks are expected to be useful for validating claims surrounding exceptional old age.
Ülke:Kérwá
Kurum:Universidad de Costa Rica
Repositorio:Kérwá
Dil:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/88492
Online Erişim:https://link.springer.com/article/10.1007/s11357-023-00731-7
https://hdl.handle.net/10669/88492
Anahtar Kelime:GENES
MORTALITY

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