Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection.

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書誌詳細
著者:	Castro Córdova, Pablo, Mora Uribe, Paola, Reyes Ramírez, Rodrigo, Cofré Araneda, Glenda, Orozco Aguilar, Josué, Brito Silva, Christian, Mendoza León, María José, Kuehne, Sarah Anna, Minton, Nigel Peter, Pizarro Guajardo, Marjorie, Paredes Sabja, Daniel
フォーマット:	artículo original
出版日付:	2021
その他の書誌記述:	Clostridioides difficile spores produced during infection are important for the recurrence of the disease. Here, we show that C. difficile spores gain entry into the intestinal mucosa via pathways dependent on host fibronectin-α5β1 and vitronectin-αvβ1. The exosporium protein BclA3, on the spore surface, is required for both entry pathways. Deletion of the bclA3 gene in C. difficile, or pharmacological inhibition of endocytosis using nystatin, leads to reduced entry into the intestinal mucosa and reduced recurrence of the disease in a mouse model. Our findings indicate that C. difficile spore entry into the intestinal barrier can contribute to spore persistence and infection recurrence, and suggest potential avenues for new therapies.
国:	Kérwá
機関:	Universidad de Costa Rica
Repositorio:	Kérwá
言語:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/87080
オンライン･アクセス:	https://www.nature.com/articles/s41467-021-21355-5.pdf https://hdl.handle.net/10669/87080
キーワード:	Clostridioides difficile Spores Disease