The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa

Guardat en:

Dades bibliogràfiques
Autors:	Molina Castro, Silvia Elena, Tiffon, Camille, Giraud, Julie, Boeuf, Hélène, Sifré, Elodie, Giese, Alban, Belleannée, Geneviève, Lethours, Philippe, Bessède, Emilie, Mégraud, Francis, Dubus, Pierre, Staedel, Cathy, Varon, Christine
Format:	artículo original
Data de publicació:	2020
Descripció:	Gastric carcinoma is related mostly to CagA+-Helicobacter pylori infection, which disrupts the gastric mucosa turnover and elicits an epithelial-mesenchymal transition (EMT) and preneoplastic transdifferentiation. The tumor suppressor Hippo pathway controls stem cell homeostasis; its core, constituted by the large tumor suppressor 2 (LATS2) kinase and its substrate Yes-associated protein 1 (YAP1), was investigated in this context.
Pais:	Kérwá
Institution:	Universidad de Costa Rica
Repositorio:	Kérwá
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/82160
Accés en línia:	https://www.cmghjournal.org/article/S2352-345X(19)30143-2/fulltext https://hdl.handle.net/10669/82160
Paraula clau:	YAP1 Epithelial-to-Mesenchymal Transition Adenocarcinoma CagA