The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa

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Detalles Bibliográficos
Autores:	Molina Castro, Silvia Elena, Tiffon, Camille, Giraud, Julie, Boeuf, Hélène, Sifré, Elodie, Giese, Alban, Belleannée, Geneviève, Lethours, Philippe, Bessède, Emilie, Mégraud, Francis, Dubus, Pierre, Staedel, Cathy, Varon, Christine
Data de Publicación:	2020
Descripción:	Gastric carcinoma is related mostly to CagA+-Helicobacter pylori infection, which disrupts the gastric mucosa turnover and elicits an epithelial-mesenchymal transition (EMT) and preneoplastic transdifferentiation. The tumor suppressor Hippo pathway controls stem cell homeostasis; its core, constituted by the large tumor suppressor 2 (LATS2) kinase and its substrate Yes-associated protein 1 (YAP1), was investigated in this context.
País:	Kérwá
Institución:	Universidad de Costa Rica
Repositorio:	Kérwá
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/82160
Acceso en liña:	https://www.cmghjournal.org/article/S2352-345X(19)30143-2/fulltext https://hdl.handle.net/10669/82160 https://doi.org/10.1016/j.jcmgh.2019.10.007
Palabra crave:	YAP1 Epithelial-to-Mesenchymal Transition Adenocarcinoma CagA