Microfluidic systems and devices for molecular capture, manipulation, and analysis
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| Autori: | , , , |
|---|---|
| Natura: | |
| Data di pubblicazione: | 2018 |
| Descrizione: | Methods, systems, and devices are disclosed for molecular capture, manipulation, and analysis. In one aspect, a device to aggregate and characterize particles in a fluid includes an electrically insulative substrate including a channel to carry an electrically conducting fluid containing particles, electrodes located in the channel forming a nanoscale opening and including an insulating layer over their surface at the opening, a first circuit to apply a non-uniform ac electric field and a dc bias signal across the electrodes, in which the applied non-uniform ac electric field produces a positive dielectrophoretic force to aggregate the particles in a trapping region including the opening and adjacent region, a second circuit to detect changes in a dc current caused by at least some of the particles in the trapping region, and an optical device that directs a coherent light beam on the opening to determine Raman spectra of the particles in the trapping region. |
| Stato: | Kérwá |
| Istituzione: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Lingua: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/91927 |
| Accesso online: | https://patentcenter.uspto.gov/applications/13872013 https://hdl.handle.net/10669/91927 |
| Keyword: | molecular capture |