Individual differences in animal models: an approach to study neurobiological factors related to depression
Tallennettuna:
| Tekijät: | , |
|---|---|
| Aineistotyyppi: | artículo original |
| Tila: | Versión publicada |
| Julkaisupäivä: | 2014 |
| Kuvaus: | The study of individual differences in the forced swimming test (FST) in rats allows the identification of either susceptibility or resilience factors in the development of depression-related behaviors. In order to study these differences several rat groups were subjected to the FST. Afterward, animals with low and high immobility were compared, which allowed us to identify a number of features that could function as risk or protection factors. Thus, neurobiological factors such as the expression levels of the corticotropin-releasing factor receptor 1 (CRFR1) in the nucleus accumbens, a differential accumbal dopamine turnover and the differential expression kinetics of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex, could play an important role in the modulation of depressive behaviors. The current review summarizes our key results in such research line. |
| Maa: | Portal de Revistas UCR |
| Organisaatio: | Universidad de Costa Rica |
| Repositorio: | Portal de Revistas UCR |
| Kieli: | Español |
| OAI Identifier: | oai:portal.revistas.ucr.ac.cr:article/5545 |
| Linkit: | https://revistas.ucr.ac.cr/index.php/ap/article/view/5545 |
| Sanahaku: | Individual differences forced swimming test behavior gene expression brain Diferencias individuales prueba de nado forzado conducta expresión génica cerebro |