Individual differences in animal models: an approach to study neurobiological factors related to depression
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| Autores: | , |
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| Formato: | artículo original |
| Estado: | Versión publicada |
| Fecha de Publicación: | 2014 |
| Descrição: | The study of individual differences in the forced swimming test (FST) in rats allows the identification of either susceptibility or resilience factors in the development of depression-related behaviors. In order to study these differences several rat groups were subjected to the FST. Afterward, animals with low and high immobility were compared, which allowed us to identify a number of features that could function as risk or protection factors. Thus, neurobiological factors such as the expression levels of the corticotropin-releasing factor receptor 1 (CRFR1) in the nucleus accumbens, a differential accumbal dopamine turnover and the differential expression kinetics of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex, could play an important role in the modulation of depressive behaviors. The current review summarizes our key results in such research line. |
| País: | Portal de Revistas UCR |
| Recursos: | Universidad de Costa Rica |
| Repositorio: | Portal de Revistas UCR |
| Idioma: | Español |
| OAI Identifier: | oai:portal.ucr.ac.cr:article/14115 |
| Acesso em linha: | https://revistas.ucr.ac.cr/index.php/actualidades/article/view/14115 |
| Palavra-chave: | Diferencias individuales prueba de nado forzado conducta expresión génica cerebro Individual differences forced swimming test behavior gene expression brain |