Individual differences in animal models: an approach to study neurobiological factors related to depression
সংরক্ষণ করুন:
| লেখক: | , |
|---|---|
| বিন্যাস: | artículo original |
| বর্তমান অবস্থা: | Versión publicada |
| প্রকাশনার তারিখ: | 2014 |
| বিবরন: | The study of individual differences in the forced swimming test (FST) in rats allows the identification of either susceptibility or resilience factors in the development of depression-related behaviors. In order to study these differences several rat groups were subjected to the FST. Afterward, animals with low and high immobility were compared, which allowed us to identify a number of features that could function as risk or protection factors. Thus, neurobiological factors such as the expression levels of the corticotropin-releasing factor receptor 1 (CRFR1) in the nucleus accumbens, a differential accumbal dopamine turnover and the differential expression kinetics of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex, could play an important role in the modulation of depressive behaviors. The current review summarizes our key results in such research line. |
| দেশ: | Portal de Revistas UCR |
| প্রতিষ্ঠান: | Universidad de Costa Rica |
| Repositorio: | Portal de Revistas UCR |
| ভাষা: | Español |
| OAI Identifier: | oai:archivo.portal.ucr.ac.cr:article/14115 |
| অনলাইন ব্যবহার করুন: | https://archivo.revistas.ucr.ac.cr/index.php/actualidades/article/view/14115 |
| মুখ্য শব্দ: | Diferencias individuales prueba de nado forzado conducta expresión génica cerebro Individual differences forced swimming test behavior gene expression brain |