Mecanismo de acción de miotoxinas aisladas de venenos de serpientes
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| Авторы: | , |
|---|---|
| Формат: | artículo original |
| Статус: | Versión publicada |
| Дата публикации: | 1984 |
| Описание: | Biochemically and pharmacologically, myotoxins isolated from snake venoms can be placed in four main groups: myolaxic phospholipases A, low molecular weight basic toxins, cardiotoxins, and hemorrhagic myotoxins. The myotoxic phospholipascs A notexin, taipoxin, crotoxin, and Bothrops asper myotoxin induce muscle necrosis by first affecting the integrity of the plasma membrane, thereby inducing a calcium influx that culminates in cell death. The small basic myotoxin crotamine acts on the voltage-sensitive sodium channels of skeletal muscle sarcolemma, inducing a sodium influx which is responsible for depolarization and contraction of skeletal muscle, as well as for vacuolization of sarcoplasmic reticulum. Cardiotoxins are basic membrane-active polypeptides that disorganize the structure of membranes; the myotoxic activity of cardiotoxins results from their ability to disrupt skeletal muscle sarcolemma. Finally, two hemorrhagic toxins (hemorrhagic toxin b and viriditoxin) are myotoxic; apparently, they induce myonecrosis secondarily to ischemia which develops in muscular tissue as a consequence of the hemorrhagic action of these toxins. |
| Страна: | Portal de Revistas UCR |
| Институт: | Universidad de Costa Rica |
| Repositorio: | Portal de Revistas UCR |
| Язык: | Español |
| OAI Identifier: | oai:archivo.portal.ucr.ac.cr:article/24516 |
| Online-ссылка: | https://archivo.revistas.ucr.ac.cr/index.php/rbt/article/view/24516 |