Evaluación de la evidencia existente sobre la efectividad de la olanzapina para el tratamiento del delirium; análisis sistemático de medicina basada en la evidencia (parte ii)
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| Autor: | |
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| Médium: | artículo original |
| Stav: | Versión publicada |
| Datum vydání: | 2011 |
| Popis: | Delirium is an acute decline of consciousness and cognition that historically has been treated with haloperidol. Because of its side effect profile, there has been a recent increase in the use of atypical antipsychotics for this indication. Objective: To systematically evaluate the literature about the use of olanzapine in the treatment of delirium using the analysis of Evidence-Based Medicine. Design: The first step was the identification of a problem, followed by the definition of a structured question, the sistematic search of the existing studies and finally the objective analysis of the validity of the results. Results: Following a search in Medline, five studies that address the issue were identified. All of them have major methodological shortcomings and in some cases there are important ethical concerns. Conclusions: First, olanzapine has a level 3 of clinical evidence for its use as a treatment for delirium. Second, a methodological improvement in the structure of these studies is urgently required, acompanied by the strict application of the ethical principles of research. Third, the DRS is a widely used scale to quantify the severity of delirium. Forth, a critical review of the literature is essencial to assess the scientific evidence. |
| Země: | Portal de Revistas UCR |
| Instituce: | Universidad de Costa Rica |
| Repositorio: | Portal de Revistas UCR |
| Jazyk: | Español |
| OAI Identifier: | oai:archivo.portal.ucr.ac.cr:article/7861 |
| On-line přístup: | https://archivo.revistas.ucr.ac.cr/index.php/medica/article/view/7861 |
| Klíčové slovo: | olanzapina medicina basada en la evidencia antipsicóticos atípicos delirium olanzapine evidence-based medicine atypical antipsychotics |