Histomorphometric Evaluation of Elastosis in Actinic Cheilitis
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| 著者: | , , |
|---|---|
| フォーマット: | artículo original |
| 状態: | Versión publicada |
| 出版日付: | 2016 |
| その他の書誌記述: | Actinic cheilitis (AC) is a potentially malignant lesion of the lip characterized by basophilic degeneration of the extracellular matrix (ECM) as a result of chronic exposure to sunlight. This alteration, known as actinic elastosis, has not been previously characterized by histomorphometry in AC and normal lip tissues (NL). METHODS: Formalin-fixed and paraffin-embedded samples of AC (n=33) and NL (n=16) obtained from the Archives of the College of Dentistry of the University of Concepción, were stained with Verhoeff-Van Giesson technique. Elastic fibers were characterized and quantified by histomorphometry using Image J Program (NIH Image). RESULTS: In AC, elastin fibers were disorganized and increased in thickness and collagen fibers looked degenerated. A significant increase in elastin fibers was found in AC as compared to NL (p<0.05). The ratio between elastin/collagen fibers was also higher in AC than NL (p<0.02). However, collagen fiber density was similar between AC and NL. A negative correlation between elastic and collagen fibers was found in AC (p<0.0001, r=0.6). Conclusions: Using histomorphometry we found a significant difference in the composition of the ECM in AC as compared to NL. This difference was mainly due to the increase in elastin fiber content in AC. |
| 国: | Portal de Revistas UCR |
| 機関: | Universidad de Costa Rica |
| Repositorio: | Portal de Revistas UCR |
| 言語: | Inglés |
| OAI Identifier: | oai:archivo.portal.ucr.ac.cr:article/26496 |
| オンライン･アクセス: | https://archivo.revistas.ucr.ac.cr/index.php/Odontos/article/view/26496 |
| キーワード: | Actinic cheilitis Actinic elastosis Elastin fibers Collagen fibers Photodamage |