Regulation of Brucella virulence by the two-component system BvrR/BvrS
Kaydedildi:
| Yazarlar: | , , , , , |
|---|---|
| Materyal Türü: | artículo |
| Yayın Tarihi: | 2002 |
| Diğer Bilgiler: | The Brucella BvrR/BvrS two-component regulatory system is highly similar to the regulatory and sensory proteins of Sinorhizobium and Agrobacterium necessary for endosymbiosis and pathogenicity in plants, and very similar to a putative system present in the animal pathogen Bartonella. Mutations in the bvrR or bvrS genes hamper the penetration of B. abortus in non-phagocytic cells and impairs intracellular trafficking and virulence. In contrast to virulent Brucella, BvrR/BvrS mutants do not recruit small GTPases of the Rho subfamily required for actin polymerization and penetration to cells. Dysfunction of the BvrR/BvrS system alters the outer membrane permeability, the expression of several group 3 outer membrane proteins and the pattern of lipid A acylation. Constructs of virulent B. abortus chimeras containing heterologous LPS from the bvrS− mutant demonstrated an altered permeability to cationic peptides similar to that of the BvrR/BvrS mutants. We hypothesize that the Brucella BvrR/BvrS is a system devoted to the homeostasis of the outer membrane and, therefore in the interface for cell invasion and mounting the required structures for intracellular parasitism. |
| Ülke: | Repositorio UNA |
| Kurum: | Universidad Nacional de Costa Rica |
| Repositorio: | Repositorio UNA |
| Dil: | Inglés |
| OAI Identifier: | oai:https://repositorio.una.ac.cr:11056/18428 |
| Online Erişim: | http://hdl.handle.net/11056/18428 https://doi.org/10.1016/S0378-1135(02)00218-3 |
| Access Level: | acceso abierto |
| Anahtar Kelime: | BvrR/BvrS BRUCELOSIS BRUCELLA VIRULENCE PROTEÍNAS MEMBRANAS CELULARES |