Antimicrobial activity of the heliangolide chromolaenide and related sesquiterpene lactones
সংরক্ষণ করুন:
| লেখক: | , , |
|---|---|
| বিন্যাস: | artículo |
| প্রকাশনার তারিখ: | 1980 |
| বিবরন: | Some sesquiterpene lactones are known to exhibit antimicrobial activity [1, 2]. More recently, it has been noted that the pseudoguainolide carpesiolin inhibits the growth of Xanthomonas oryzae [3]. Here, we report on the antimicrobial activity of the heliangolide chromolaenide 1, isolated from Chromolaena glaberrima (DC.) King et Robinson [4] and its derivatives, against Staphylococcus aureus. The results are summarized in Table 1. It is apparent that there is a clear dependence between antimicrobial activity and the presence of the t~-methylene-3,- iactone group. As already established [5-8], the growth inhibition of microorganisms is caused by the alkylation of their nucleophilic centers (R-SH) with the unsaturated lactone moiety. This observation is congruent with our results, because the only inactive compound was 3, which is the one with no unsaturated lactone. |
| দেশ: | Repositorio UNA |
| প্রতিষ্ঠান: | Universidad Nacional de Costa Rica |
| Repositorio: | Repositorio UNA |
| ভাষা: | Inglés |
| OAI Identifier: | oai:null:11056/22872 |
| অনলাইন ব্যবহার করুন: | http://hdl.handle.net/11056/22872 https://doi.org/10.1016/0031-9422(80)85151-x |
| মুখ্য শব্দ: | ESTEREOQUIMICA ANTIBIÓTICOS ANTIBIOTICS ANTINFLAMATORIOS STEREOCHEMISTRY ANTI-INFLAMMATORIES |