Antimicrobial activity of the heliangolide chromolaenide and related sesquiterpene lactones
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| Autores: | , , |
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| 格式: | artículo |
| Fecha de Publicación: | 1980 |
| 实物特征: | Some sesquiterpene lactones are known to exhibit antimicrobial activity [1, 2]. More recently, it has been noted that the pseudoguainolide carpesiolin inhibits the growth of Xanthomonas oryzae [3]. Here, we report on the antimicrobial activity of the heliangolide chromolaenide 1, isolated from Chromolaena glaberrima (DC.) King et Robinson [4] and its derivatives, against Staphylococcus aureus. The results are summarized in Table 1. It is apparent that there is a clear dependence between antimicrobial activity and the presence of the t~-methylene-3,- iactone group. As already established [5-8], the growth inhibition of microorganisms is caused by the alkylation of their nucleophilic centers (R-SH) with the unsaturated lactone moiety. This observation is congruent with our results, because the only inactive compound was 3, which is the one with no unsaturated lactone. |
| País: | Repositorio UNA |
| 机构: | Universidad Nacional de Costa Rica |
| Repositorio: | Repositorio UNA |
| 语言: | Inglés |
| OAI Identifier: | oai:null:11056/22872 |
| 在线阅读: | http://hdl.handle.net/11056/22872 https://doi.org/10.1016/0031-9422(80)85151-x |
| Palabra clave: | ESTEREOQUIMICA ANTIBIÓTICOS ANTIBIOTICS ANTINFLAMATORIOS STEREOCHEMISTRY ANTI-INFLAMMATORIES |