In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
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| Nhiều tác giả: | , , , , , |
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| Định dạng: | artículo |
| Ngày xuất bản: | 2009 |
| Miêu tả: | The in vitro activity of four 2-nitropropene derivatives, 1-(3-benzothienyl)-2-nitropropene (N1), 1-(3-thienyl)-2- nitropropene (N2), 1-(5-bromo-2-thienyl)-2-nitropropene (N3) and 1-(4-bromo-2-thienyl)-2-nitropropene (N4), were tested against cultures of the parasite Trypanosoma cruzi. Cytotoxicity studies were performed using Vero cells. The blood trypomastigotes, amastigotes and epimastigotes showed differential degrees of sensitivity towards the four tested compounds; the highest activity against the epimastigotes and blood tripomastigotes was exhibited by N1, followed by N3, N4 and finally N2. In contrast, whereas the compounds N1, N3 and N4 exerted similar magnitudes of activity against amastigotes, N2 was found to be a much less potent compound. According to our results, the com pound N1 had the highest level of activity (IC50: 0.6 µM) against epimastigotes. |
| Quốc gia: | Repositorio UNA |
| Tổ chức giáo dục: | Universidad Nacional de Costa Rica |
| Repositorio: | Repositorio UNA |
| Ngôn ngữ: | Inglés |
| OAI Identifier: | oai:null:11056/23635 |
| Truy cập trực tuyến: | http://hdl.handle.net/11056/23635 |
| Từ khóa: | TRYPANOSOMA CRUZI CHAGAS DISEASE ENFERMEDAD DE CHAGAS TRYPANOSOMA |