The effect of solution environment and the electrostatic factor on the crystallisation of desmotropes of irbesartan

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Autoren:	Araya, Andrea, Urgelles, Mariola, Vásquez Castro, Felipe, Vargas-Huertas, Felipe, Jose-Roberto, Vega-Baudrit, Guillen-Girón, Teodolito, Navarro-Hoyos, Mirtha, Cuffini, Silvia Lucia
Format:	artículo
Publikationsdatum:	2019
Beschreibung:	The experimental conditions necessary for stabilising irbesartan (IBS) tautomers in solution and selectively obtaining the desmotropic crystal forms are presented herein. 1H and 2H tautomers were stabilized in specific solution conditions and the 2H-tetrazole/imidazole interaction was confirmed by solution-state NMR. The results showed that highly polar and polarisable solvents (higher values of the electrostatic factor (EF)) lead to the crystallisation of IBS form B. Furthermore, the variations of pH in methanol, in turn, determined the crystallisation of desmotropes A and/or B
Land:	Repositorio UNA
Institution:	Universidad Nacional de Costa Rica
Repositorio:	Repositorio UNA
Sprache:	Inglés
OAI Identifier:	oai:null:11056/22338
Online Zugang:	http://hdl.handle.net/11056/22338
Stichwort:	IRBESARTAN DESMOTROPIC FORMS TAUTOMERISM CRISTALIZACIÓN CRYSTALLIZATION