The antimicrobial potential of Streptomyces from insect microbiomes

 

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Awduron: Chevrette, Marc G., Carlson, Caitlin M., Ortega Dominguez, Humberto Enrique, Thomas, Christopher S., Ananiev, Gene E., Barns, Kenneth J., Book, Adam J., Cagnazzo, Julian, Carlos Shanley, Camila, Flanigan, Will, Grubbs, Kirk J., Horn, Heidi A., Hoffmann, F. Michael, Klassen, Jonathan L., Knack, Jennifer J., Lewin, Gina R., McDonald, Bradon R., Muller, Laura K., Melo, Weilan Gomes da Paixão, Pinto Tomás, Adrián A., Schmitz, Amber Marie, Wendt-Pienkowski, Evelyn, Wildman, Scott, Zhao, Miao, Zhang, Fan, Bugni, Tim S., Andes, David R., Pupo, Monica Tallarico, Currie, Cameron Robert
Fformat: artículo original
Dyddiad Cyhoeddi:2019
Disgrifiad:Antimicrobial resistance is a global health crisis and few novel antimicrobials have been discovered in recent decades. Natural products, particularly from Streptomyces, are the source of most antimicrobials, yet discovery campaigns focusing on Streptomyces from the soil largely rediscover known compounds. Investigation of understudied and symbiotic sources has seen some success, yet no studies have systematically explored microbiomes for antimicrobials. Here we assess the distinct evolutionary lineages of Streptomyces from insect microbiomes as a source of new antimicrobials through large-scale isolations, bioactivity assays, genomics, metabolomics, and in vivo infection models. Insect-associated Streptomyces inhibit antimicrobial-resistant pathogens more than soil Streptomyces. Genomics and metabolomics reveal their diverse biosynthetic capabilities. Further, we describe cyphomycin, a new molecule active against multidrug resistant fungal pathogens. The evolutionary trajectories of Streptomyces from the insect microbiome influence their biosynthetic potential and ability to inhibit resistant pathogens, supporting the promise of this source in augmenting future antimicrobial discovery.
Gwlad:Kérwá
Sefydliad:Universidad de Costa Rica
Repositorio:Kérwá
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/79896
Mynediad Ar-lein:https://www.nature.com/articles/s41467-019-08438-0#Abs1
https://hdl.handle.net/10669/79896
Allweddair:Streptomyces
Bacteria
Insect microbiome

Eitemau Tebyg