Montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis
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| Autori: | , , , , , , , , , , , , , , |
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| Data di pubblicazione: | 2023 |
| Descrizione: | Background: We aim to assess the impact of montelukast on paediatric patients with asthma/allergic rhinitis, measured using patient-reported outcome measures, compared with other treatments or placebo. Methods: Protocol registration CRD42020216098 (www.crd.york.ac.uk/PROSPERO). MEDLINE and Embase databases were used to conduct the search. Two authors independently selected studies and extracted data, and a third reviewer resolved discrepancies. Meta-analyses were constructed to estimate the standardised mean difference (SMD) using a random-effects model. Results: Out of 3937 articles identified, 49 studies met the inclusion criteria, mostly randomised clinical trials (sample sizes: 21–689 patients). The SMD of change pooled estimators for the global, mental and physical domains of health-related quality of life were not statistically significant. For daytime and nighttime symptoms scores, the SMD (95% CI) was in favour of inhaled corticosteroids (−0.12, −0.20– −0.05 and −0.23, −0.41– −0.06, respectively). The pooled estimator for global asthma symptoms was better for montelukast when compared with placebo (0.90, 0.44–1.36). Conclusions: The synthesis of the available evidence suggests that, in children and adolescents, montelukast was effective in controlling asthma symptoms when compared with placebo, but inhaled corticosteroids were superior in controlling symptoms, especially at night-time. These findings of our systematic review concur with current guidelines for asthma treatment. |
| Stato: | Kérwá |
| Istituzione: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Lingua: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/105025 |
| Accesso online: | https://hdl.handle.net/10669/105025 https://doi.org/10.1183/16000617.0124-2023 |
| Keyword: | Montelukast Pediatrics Pharmacology Medical treatment Data analysis Quality of life Asthma Allergic rhinitis |