Identification of polyphenols from antiviral Chamaecrista nictitans extract using high-resolution LC–ESI–MS/MS
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| Autores: | , , , , , |
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| Formato: | artículo original |
| Fecha de Publicación: | 2014 |
| Descripción: | Chamaecrista nictitans (L) extract possesses antiviral properties; it acts against the herpes simplex virus, and this may be attributed to its constituent phenolics. Here, high-resolution LC–ESI–MS/MS is used to identify the phenolic components of the most potent fraction of the extract. The fraction is a complex mixture rich in oligomeric proanthocyanidins with a high content of monohydroxyphenol moieties ((epi)fisetinidol, (epi)afzelechin and (epi)guibourtinidol) and A-type linkages, uncommon in other proanthocyanidin-rich phenolic extracts, such as those from grape seeds or pine bark. As monohydroxyphenolic structures and A-type linkages have been related to antiviral effects, particularly through the inhibition of late transcription, we suggest that the fraction of C. nictitans extract exerts its action through a particularly effective combination of proanthocyanidins that include these two structural features. |
| País: | Kérwá |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/87981 |
| Acceso en línea: | https://link.springer.com/article/10.1007/s00216-014-7982-6 https://hdl.handle.net/10669/87981 |
| Palabra clave: | LC–ESI–MS/MS Chamaecrista nictitans Polyphenol Proanthocyanidin Free radical scavenging activity Antiviral activity VIROLOGY |