Microevolution, Migration, and the Population Structure of Five Amerindian Populations from Nicaragua and Costa Rica
保存先:
| 著者: | , , , |
|---|---|
| フォーマット: | artículo original |
| 出版日付: | 2013 |
| その他の書誌記述: | Objective: This research examines the coevolution of languages and uniparental genetic marker (mitochondrial DNA [mtDNA] and nonrecombining Y-chromosome [NRY]) variation within five Lower Central American (Rama, Chorotega, Mal eku, Zapat on-Huetar, and Abrojo-Guaym ı) Amerindian groups. This pattern occurred since European contact. Methods: We examined mtDNA sequence variation from the hypervariable region 1 (HVS-1) and NRY genetic variation using short tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, and DYS439) and NRY haplogroups (Q1a3a, Q1a3*, C3b, R1b1b2, E1b1, G2a2, and I) identified through single-nucleotide polymorphisms. Phylogenetic analysis included multidimensional scaling (MDS), heterozygosity versus rii, and analysis of molecular variance (AMOVA). Results: Eighteen mtDNA haplotypes were characterized in 131 participants with 94.6% of these assigned to the Amerindian mtDNA subclades, A2 and B2. The Amerindian NRY haplogroup, Q1a3a, was present in all five groups and ranged from 85% (Zapat on-Huetar) to 35% (Chorotega). Four populations (Rama, Chorotega, Zapat on-Huetar, and Abrojo-Guaym ı) were also characterized by the presence of NRY haplogroup R1b1b2 indicative of western European admixture. Seventy NRY STR haplotypes were identified of which 69 (97%) were population specific. MDS plots demonstrated genetic similarities between Mesoamericans and northern Chibchan Amerindian populations, absent in mtDNA analyses, which is further supported by heterozygosity versus rii results. Conclusions: We conclude that although these linguistically related populations in geographic proximity demonstrate a high degree of paternal genetic differentiation, recent demographic events have dramatically altered the paternal genetic structure of the regions Amerindian populations |
| 国: | Kérwá |
| 機関: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| 言語: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/83124 |
| オンライン･アクセス: | https://pubmed.ncbi.nlm.nih.gov/23559443/ https://hdl.handle.net/10669/83124 |
| キーワード: | Population structure Mitochondrial DNA NRY STRs Central America Microevolution Indigenous populations Cibchan speakers |