Bioassay-guided isolation of anti-inflammatory O-sulfated withanolides from Acnistus arborescens (Solanaceae)

 

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Autoři: Steinbrueck, Clara, Mora Ugalde, Nohelia, Morales Sánchez, Carlos, Loaiza Montoya, Randall, García Piñeres, Alfonso J., Araya Barrantes, Juan José
Médium: artículo original
Datum vydání:2019
Popis:Bioassay-guided fractionation of Acnistus arborescens (Solanaceae) organic extract afforded two anti-inflammatory withanolides: 2,3-Dihydro-3β-O-sulfate withacnistin (1) and 2,3-Dihydro-3β-O-sulfate withaferin A (2) showing IC50 values of 1.0 ± 0.1 and 14 ± 1 μM respectively in a LPS-stimulated RAW 264.7 murine macrophage assay. These compounds were also evaluated against two selected cancer cell lines showing significant cytotoxicity. Although there are several reports dealing with the chemistry of this species, we report for the first time the isolation of O-sulfated withanolides.
Země:Kérwá
Instituce:Universidad de Costa Rica
Repositorio:Kérwá
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/78890
On-line přístup:https://www.sciencedirect.com/science/article/pii/S1874390018302556#!
https://hdl.handle.net/10669/78890
Klíčové slovo:Acnistus arborescens
Anti-inlammatory
Sulfated withanolides
Cytotoxicity