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Formulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils

 

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Autores: González Corrales, Daniela, Monge Quirós, Tatiana, Chavarría Rojas, Marianela, Rojas Campos, Norman, Cruz Sibaja, Wendy, Madrigal Redondo, German
格式: artículo original
Fecha de Publicación:2021
实物特征:Background: Periodontal disease is the infection and inflammation of the gums, bones, and tissues involved in teeth support, and it is one of the most common diseases affecting pet dogs. Essential oils have shown antimicrobial activity against bacteria causing periodontal disease; therefore, they are considered potential therapeutic agents. Objectives: The main objective was to formulate and evaluate the antimicrobial activity of a 0.2% chlorhexidine canine mouthwash with essential oils. Methods: Three microemulsion formulations were obtained by constructing a pseudo-ternary phase diagram using the phase titration method. Different surfactant agents were evaluated, and hydrogenated castor oil was selected as the emulsifier agent. The antimicrobial activity of oregano essential oil (Origanum vulgare), thyme essential oil (Thymus vulgaris), and the three formulations were evaluated against Staphylococcus aureus, Streptococcus mutans, Streptococcus salivarius, and Escherichia coli. Results: Pure thyme and oregano essential oils showed higher antimicrobial activity than a 0,2% chlorhexidine solution. The formulations with essential oils plus chlorhexidine and chlorhexidine alone showed antimicrobial activity. The formulation containing only essential oils did not show antimicrobial activity. Conclusions: A canine mouthwash was formulated with chlorhexidine and thyme and oregano essential oil. Based on the evaluation of antimicrobial activity, two of the proposed formulations could be a therapeutic option to reduce the risk and prevent periodontal disease in canines.
País:Kérwá
机构:Universidad de Costa Rica
Repositorio:Kérwá
语言:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/86981
在线阅读:https://revistas.udea.edu.co/index.php/vitae/article/view/341703
https://hdl.handle.net/10669/86981
Palabra clave:Periodontitis
Microemulsion
Oregano
Thyme
Chlorhexidine
Essential oil