Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA2 from Bothrops asper venom
Kaydedildi:
| Yazarlar: | , , , , , , |
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| Materyal Türü: | artículo original |
| Yayın Tarihi: | 2004 |
| Diğer Bilgiler: | Suramin is a highly charged polysulfonated napthylurea that interferes in a number of physiologically relevant processes such as myotoxicity, blood coagulation and several kinds of cancers. This synthetic compound was complexed with a myotoxic Lys49 PLA2 from Bothrops asper venom and crystallized by the hanging-drop vapor diffusion method at 18 °C. The crystals belong to the orthorhombic space group P212121, with unit cell parameters a=49.05, b=63.84 and c=85.67 Å. Diffraction data was collected to 1.78 Å. |
| Ülke: | Kérwá |
| Kurum: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/29546 |
| Online Erişim: | http://www.sciencedirect.com/science/article/pii/S1570963904002201 https://hdl.handle.net/10669/29546 |
| Anahtar Kelime: | Suramin Myotoxicity Lys49 PLA2s X-Ray Diffraction Snake venom |