Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA2 from Bothrops asper venom

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Bibliographic Details
Authors:	Murakami, Mário T., Gava, Lisandra M., Zela, Sandro P., Arruda, Emerson Z., Melo, Paulo A., Gutiérrez, José María, Arni, Raghuvir K.
Format:	artículo original
Publication Date:	2004
Description:	Suramin is a highly charged polysulfonated napthylurea that interferes in a number of physiologically relevant processes such as myotoxicity, blood coagulation and several kinds of cancers. This synthetic compound was complexed with a myotoxic Lys49 PLA2 from Bothrops asper venom and crystallized by the hanging-drop vapor diffusion method at 18 °C. The crystals belong to the orthorhombic space group P212121, with unit cell parameters a=49.05, b=63.84 and c=85.67 Å. Diffraction data was collected to 1.78 Å.
Country:	Kérwá
Institution:	Universidad de Costa Rica
Repositorio:	Kérwá
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/29546
Online Access:	http://www.sciencedirect.com/science/article/pii/S1570963904002201 https://hdl.handle.net/10669/29546
Keyword:	Suramin Myotoxicity Lys49 PLA2s X-Ray Diffraction Snake venom