Mapping the immune cell microenvironment with spatial profiling in muscle tissue injected with the venom of Daboia russelii
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| Autori: | , , , , , , , |
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| Natura: | artículo original |
| Data di pubblicazione: | 2023 |
| Descrizione: | Snake venoms induce tissue damage and inflammation which vary in different regions of the tissue. Understanding such heterogeneity in the immune cell microenvironment that follows acute tissue damage induced by venoms is, therefore, relevant. In this study, the methodology of digital spatial profiling was used, in combination with histology and immunohistochemistry, to quantify markers of immune cells in regions of muscle tissue having different extents of Daboia russelii venom-induced damage. A heterogeneous scenario of immune cells was observed, which may have implications for the processes of tissue repair and regeneration. |
| Stato: | Kérwá |
| Istituzione: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Lingua: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/103143 |
| Accesso online: | https://hdl.handle.net/10669/103143 https://doi.org/10.3390/toxins15030208 |
| Keyword: | Daboia russelii venom myonecrosis desmin inflammatory infiltrate |