Vertical Transmission in a Two-Strain Model of Dengue Fever
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| Autores: | , , , , |
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| Formato: | artículo original |
| Fecha de Publicación: | 2014 |
| Descripción: | The role of vertical transmission in vectors has rarely been addressed in the study of dengue dynamics and control, in part because it was not considered a critical population-level factor. In this paper, we apply the pioneering model- ing ideas of Ross and MacDonald, motivated by the context of the 2000–2001 dengue outbreak in Peru, to assess the dynamics of multi-strain competition. An invading strain of dengue virus (DENV-2) from Asia rapidly circulated into Peru eventually displacing DENV-2 American. A host-dengue model that con- siders the competing dynamics of these two DENV-2 genotypes, the resident or the American type and the invasive more virulent Asian strain, is introduced and analyzed. The model incorporates vertical transmission by DENV-2 Asian a potentially advantageous trait. Conditions for competitive exclusion of dengue strains are established. The model is used to show that lower transmission rates of DENV-2 Asian are sufficient for displacing DENV-2 American in the presence of vertical transmission. |
| País: | Kérwá |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/75903 |
| Acceso en línea: | https://www.tandfonline.com/doi/abs/10.1080/23737867.2014.11414484 https://hdl.handle.net/10669/75903 |
| Palabra clave: | Modelo matemático Modelos epidémicos Matemática aplicada Dengue Transmisión vertical Vector-host model Epidemiology Vertical transmission Peru 616.921 Fiebre de dengue |