Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu
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| Autores: | , , , , , |
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| Formato: | artículo original |
| Fecha de Publicación: | 2007 |
| Descripción: | The local and systemic pathophysiological alterations induced by BjussuSP-I, a thrombin-like serine proteinase from the venom of the snake Bothrops jararacussu, were assessed in mice. BjussuSP-I induced a mild edema but no local myonecrosis or hemorrhage. It did not induce any microvascular alteration in the cremaster muscle. Intramuscular injection of BjussuSP-I promoted an increase in the expression of proMMP-9, but it did not induce the activation of proMMP-2 or proMMP-9 synthesized in muscle tissue injected with a myotoxic phospholipase A2 homolog. BjussuSP-I induced defibrin(ogen)ation upon intravenous and intramuscular injections, with reduction in plasma fibrinogen concentration and increments in the levels of fibrin degradation products and D-dimer. When compared with animals having normal coagulation, mice defibrin(ogen)ated by BjussuSP-I developed a slightly larger hemorrhagic lesion in the skin when injected with metalloproteinase BaP1. Intravenous injection of sublethal doses of BjussuSP-I promoted a series of behavioral and motor changes similar to those previously described for ‘gyroxin’, i.e. opisthotonus and a circular body movement along the longitudinal axis. |
| País: | Kérwá |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/29382 |
| Acceso en línea: | http://www.sciencedirect.com/science/article/pii/S0041010106004764 https://hdl.handle.net/10669/29382 |
| Access Level: | acceso abierto |
| Palabra clave: | Thrombin-like Bothrops Jararacussu MMPs Serine Proteinase Defibrin(ogen)ation |