Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose
Guardado en:
| Autores: | , , , , , |
|---|---|
| Formato: | artículo original |
| Fecha de Publicación: | 2010 |
| Descripción: | We report the proteomic characterization and biological activities of the venom of the black-speckled palm pitviper, Bothriechis nigroviridis, a neotropical arboreal pitviper from Costa Rica. In marked contrast to other Bothriechis species investigated, the venom of B. nigroviridis does not possess detectable Zn2+-dependent metalloproteinases, and is uniquely characterized by a high content of crotoxin-like PLA2 and vasoactive peptides. These data suggest that different evolutionary solutions have evolved within the arboreal genus Bothriechis for the same trophic purpose. The venom from B. nigroviridis is devoid of hemorrhagic activity, has low edematogenic and coagulant effects, presents modest myotoxic and phospholipase A2 activities, but has higher lethality than the venoms of other Bothriechis species. Neutralization of its lethal activity by an anti-Crotalus durissus terrificus antivenom confirmed the major role of crotoxin-like PLA2 in B. nigroviridis venom-induced lethality. |
| País: | Kérwá |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/29314 |
| Acceso en línea: | http://pubs.acs.org/doi/abs/10.1021/pr100545d https://hdl.handle.net/10669/29314 |
| Palabra clave: | Black-speckled palm pitviper Bothriechis nigroviridis Mass Spectrometry N-terminal Sequencing Snake venom proteomics Venomics Snake venom |