Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats
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Authors: | , , , , , , , , , , , |
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Format: | artículo original |
Publication Date: | 2022 |
Description: | In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations |
Country: | Kérwá |
Institution: | Universidad de Costa Rica |
Repositorio: | Kérwá |
Language: | Inglés |
OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/88017 |
Online Access: | https://www.sciencedirect.com/science/article/abs/pii/S0041010122001167?via%3Dihub https://hdl.handle.net/10669/88017 |
Keyword: | Micrurus varespladib SUSTANCIA PELIGROSA Snake venom |