Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats

 

সংরক্ষণ করুন:
গ্রন্থ-পঞ্জীর বিবরন
লেখক: Silva Carvalho, Rosimeire, Gaspar, Matheus Z., Quadros, Luiz H. B., Lobo, Luís G. G., Giuffrida, Rogério, Santarém, Cecília L., Silva, Elisangela O., Gerez, Juliana Rubira, Silva, Nelson J., Hyslop, Stephen, Lomonte, Bruno, Floriano, Rafael Stuani
বিন্যাস: artículo original
প্রকাশনার তারিখ:2022
বিবরন:In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations
দেশ:Kérwá
প্রতিষ্ঠান:Universidad de Costa Rica
Repositorio:Kérwá
ভাষা:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/88017
অনলাইন ব্যবহার করুন:https://www.sciencedirect.com/science/article/abs/pii/S0041010122001167?via%3Dihub
https://hdl.handle.net/10669/88017
মুখ্য শব্দ:Micrurus
varespladib
SUSTANCIA PELIGROSA
Snake venom

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