Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats

 

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون: Silva Carvalho, Rosimeire, Gaspar, Matheus Z., Quadros, Luiz H. B., Lobo, Luís G. G., Giuffrida, Rogério, Santarém, Cecília L., Silva, Elisangela O., Gerez, Juliana Rubira, Silva, Nelson J., Hyslop, Stephen, Lomonte, Bruno, Floriano, Rafael Stuani
التنسيق: artículo original
تاريخ النشر:2022
الوصف:In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations
البلد:Kérwá
المؤسسة:Universidad de Costa Rica
Repositorio:Kérwá
اللغة:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/88017
الوصول للمادة أونلاين:https://www.sciencedirect.com/science/article/abs/pii/S0041010122001167?via%3Dihub
https://hdl.handle.net/10669/88017
كلمة مفتاحية:Micrurus
varespladib
SUSTANCIA PELIGROSA
Snake venom

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