Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats

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Autors:	Silva Carvalho, Rosimeire, Gaspar, Matheus Z., Quadros, Luiz H. B., Lobo, Luís G. G., Giuffrida, Rogério, Santarém, Cecília L., Silva, Elisangela O., Gerez, Juliana Rubira, Silva, Nelson J., Hyslop, Stephen, Lomonte, Bruno, Floriano, Rafael Stuani
Format:	artículo original
Data de publicació:	2022
Descripció:	In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations
Pais:	Kérwá
Institution:	Universidad de Costa Rica
Repositorio:	Kérwá
Idioma:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/88017
Accés en línia:	https://www.sciencedirect.com/science/article/abs/pii/S0041010122001167?via%3Dihub https://hdl.handle.net/10669/88017
Paraula clau:	Micrurus varespladib SUSTANCIA PELIGROSA Snake venom