Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats

 

שמור ב:
מידע ביבליוגרפי
Autores: Silva Carvalho, Rosimeire, Gaspar, Matheus Z., Quadros, Luiz H. B., Lobo, Luís G. G., Giuffrida, Rogério, Santarém, Cecília L., Silva, Elisangela O., Gerez, Juliana Rubira, Silva, Nelson J., Hyslop, Stephen, Lomonte, Bruno, Floriano, Rafael Stuani
פורמט: artículo original
Fecha de Publicación:2022
תיאור:In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations
País:Kérwá
מוסד:Universidad de Costa Rica
Repositorio:Kérwá
שפה:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/88017
גישה מקוונת:https://www.sciencedirect.com/science/article/abs/pii/S0041010122001167?via%3Dihub
https://hdl.handle.net/10669/88017
מילת מפתח:Micrurus
varespladib
SUSTANCIA PELIGROSA
Snake venom

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