Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats

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Nhiều tác giả:	Silva Carvalho, Rosimeire, Gaspar, Matheus Z., Quadros, Luiz H. B., Lobo, Luís G. G., Giuffrida, Rogério, Santarém, Cecília L., Silva, Elisangela O., Gerez, Juliana Rubira, Silva, Nelson J., Hyslop, Stephen, Lomonte, Bruno, Floriano, Rafael Stuani
Định dạng:	artículo original
Ngày xuất bản:	2022
Miêu tả:	In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations
Quốc gia:	Kérwá
Tổ chức giáo dục:	Universidad de Costa Rica
Repositorio:	Kérwá
Ngôn ngữ:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/88017
Truy cập trực tuyến:	https://www.sciencedirect.com/science/article/abs/pii/S0041010122001167?via%3Dihub https://hdl.handle.net/10669/88017
Từ khóa:	Micrurus varespladib SUSTANCIA PELIGROSA Snake venom