The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

 

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Detalles Bibliográficos
Autores: Thorell, Kaisa, Muñoz Ramírez, Zilia Yanira, Wang, Difei, Sandoval Motta, Santiago, Boscolo Agostini, Rajiv, Ghirotto, Silvia, Torres, Roberto C., Falush, Daniel, Camargo, M. Constanza, Rabkin, Charles S., Wan, Yunhu, Hicks, Belynda, Zhu, Bin, Yeager, Meredith, Hutchinson, Amy, Teshome, Kedest, Jones, Kristie, Luo, Wen, Goldstein, Alisa M., Hu, Nan, Taylor, Philip R., Song, Minkyo, Gutiérrez Escobar, Andrés J., Yu, Kai, Abnet, Christian C., Chanock, Stephen J., Romero Gallo, Judith, Krishna, Uma, Peek, Richard M., Piazuelo, M. Blanca, Wilson, Keith T., Loh, John T., Cover, Timothy L., Raaf, Naïma, Bentolila, Federico, Aftab, Hafeza, Akada, Junko, Matsumoto, Takashi, Yamaoka, Yoshio, Haesebrouck, Freddy, Colanzi, Rony P., Bartelli, Thais F., Nunes, Diana Noronha, Pelosof, Adriane, Zitron Sztokfisz, Claudia, Dias Neto, Emmanuel, Assumpção, Paulo Pimentel, Tishkov, Ivan, Kouitcheu Mabeku, Laure Brigitte, Goodman, Karen J., Geary, Janis, Cromarty, Taylor J., Price, Nancy L., Quilty, Douglas, Corvalan, Alejandro H., Serrano, Carolina A., Gonzalez, Robinson, Riquelme, Arnoldo, García Cancino, Apolinaria, Parra Sepúlveda, Cristian, Bernal, Giuliano, Castillo, Francisco, Bravo, Maria Mercedes, Pazos, Alvaro, Bravo, Luis E., Fox, James G., Ramírez Mayorga, Vanessa, Molina Castro, Silvia, Durán Bermúdez, Sundry, Campos Núñez, Christian, Chaves Cervantes, Manuel, Tshibangu Kabamba, Evariste, Tumba, Ghislain Disashi, Tshimpi Wola, Antoine, Ngoma Kisoko, Patrick de Jesus, Ngoyi, Dieudonné Mumba, Cruz, Modesto, Hosking, Celso, Jiménez Abreu, José, Varon, Christine, Benejat, Lucie, Jehanne, Quentin, Lehours, Philippe, Megraud, Francis, Secka, Ousman, Link, Alexander, Malfertheiner, Peter, Adinortey, Michael Buenor, Bockarie, Ansumana Sandy, Ayefoumi Adinortey, Cynthia, Gyamerah Ofori, Eric, Sgouras, Dionyssios N., Martinez Gonzalez, Beatriz, Michopoulos, Spyridon, Georgopoulos, Sotirios, Hernandez, Elisa, Volga Tacatic, Braulio, Aguilar, Mynor, Dominguez, Ricardo L., Morgan, Douglas R., Harðardóttir, Hjördís, Gunnarsdóttir, Anna Ingibjörg, Guðjónsson, Hallgrímur, Jónasson, Jón Gunnlaugur, Björnsson, Einar S., Ballal, Mamatha, Shetty, Vignesh
Formato: artículo original
Fecha de Publicación:2023
Descripción:Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H.pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNor-thAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics.
País:Kérwá
Institución:Universidad de Costa Rica
Repositorio:Kérwá
Lenguaje:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/99997
Acceso en línea:https://hdl.handle.net/10669/99997
https://doi.org/10.1038/s41467-023-43562-y
Palabra clave:Bacterial genetics
Bacterial genomics
Pathogens
Population genetics

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