Potent nor-triterpenoid blockers of the voltage-gated potassium channel Kv1.3 from Spachea correae

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書誌詳細
著者:	Goetz, Michael A., Hensens, Otto D., Zink, Deborah L., Borris, Robert P., Morales Quirós, Juan Francisco, Tamayo Castillo, Giselle, Slaughter, Robert S., Felix, John P., Ball, Richard G.
フォーマット:	artículo original
出版日付:	1998
その他の書誌記述:	The isolation and structure elucidation of two novel nor-triterpenoid KV1.3 potassium channel blockers correolide and dehydrocorreolide from the Costa Rican tree Spachea correae are reported. The first potent and selective small molecule blockers of KV 1.3, cprreolide (1) and its dehydro derivative 2 have been identified from extracts of Spachea correoe. Agents that inhibit the opening of this voltage-gated potassium channel can be expected to have immunosuppressive properties.
国:	Kérwá
機関:	Universidad de Costa Rica
Repositorio:	Kérwá
言語:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/87847
オンライン･アクセス:	https://www.sciencedirect.com/science/article/pii/S0040403998004274#! https://hdl.handle.net/10669/87847
キーワード:	Kv1.3 channel blockers correolide and dehydrocorreolide Isolation and structure 2D NMR HMBC EI-MS X-ray