Potent nor-triterpenoid blockers of the voltage-gated potassium channel Kv1.3 from Spachea correae

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Auteurs:	Goetz, Michael A., Hensens, Otto D., Zink, Deborah L., Borris, Robert P., Morales Quirós, Juan Francisco, Tamayo Castillo, Giselle, Slaughter, Robert S., Felix, John P., Ball, Richard G.
Format:	artículo original
Date de publication:	1998
Description:	The isolation and structure elucidation of two novel nor-triterpenoid KV1.3 potassium channel blockers correolide and dehydrocorreolide from the Costa Rican tree Spachea correae are reported. The first potent and selective small molecule blockers of KV 1.3, cprreolide (1) and its dehydro derivative 2 have been identified from extracts of Spachea correoe. Agents that inhibit the opening of this voltage-gated potassium channel can be expected to have immunosuppressive properties.
Pays:	Kérwá
Institution:	Universidad de Costa Rica
Repositorio:	Kérwá
Langue:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/87847
Accès en ligne:	https://www.sciencedirect.com/science/article/pii/S0040403998004274#! https://hdl.handle.net/10669/87847
Mots-clés:	Kv1.3 channel blockers correolide and dehydrocorreolide Isolation and structure 2D NMR HMBC EI-MS X-ray