Potent nor-triterpenoid blockers of the voltage-gated potassium channel Kv1.3 from Spachea correae

 

שמור ב:
מידע ביבליוגרפי
Autores: Goetz, Michael A., Hensens, Otto D., Zink, Deborah L., Borris, Robert P., Morales Quirós, Juan Francisco, Tamayo Castillo, Giselle, Slaughter, Robert S., Felix, John P., Ball, Richard G.
פורמט: artículo original
Fecha de Publicación:1998
תיאור:The isolation and structure elucidation of two novel nor-triterpenoid KV1.3 potassium channel blockers correolide and dehydrocorreolide from the Costa Rican tree Spachea correae are reported. The first potent and selective small molecule blockers of KV 1.3, cprreolide (1) and its dehydro derivative 2 have been identified from extracts of Spachea correoe. Agents that inhibit the opening of this voltage-gated potassium channel can be expected to have immunosuppressive properties.
País:Kérwá
מוסד:Universidad de Costa Rica
Repositorio:Kérwá
שפה:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/87847
גישה מקוונת:https://www.sciencedirect.com/science/article/pii/S0040403998004274#!
https://hdl.handle.net/10669/87847
מילת מפתח:Kv1.3 channel blockers correolide and dehydrocorreolide
Isolation and structure
2D NMR
HMBC
EI-MS
X-ray

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