Pros and cons of different therapeutic antibody formats for recombinant antivenom development

 

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Dades bibliogràfiques
Autors: Laustsen, Andreas Hougaard, Gutiérrez, José María, Knudsen, Cecilie, Johansen, Kristoffer H., Bermúdez Méndez, Erick, Cerni, Felipe A., Jürgensen, Jonas A., Ledsgaard, Line, Martos Esteban, Andrea, Øhlenschlæger, Mia, Pus, Urska, Andersen, Mikael Rørdam, Lomonte, Bruno, Engmark, Mikael Gerling, Pucca, Manuela Berto
Format: artículo original
Data de publicació:2018
Descripció:Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being investigated for the ability to neutralize animal toxins. These different molecular formats each have their own therapeutic characteristics. In this review, we provide an overview of the advances made in the development of toxin-targeting antibodies, and discuss the benefits and drawbacks of different antibody formats in relation to their ability to neutralize toxins, pharmacokinetic features, propensity to cause adverse reactions, formulation, and expression for research and development (R&D) purposes and large-scale manufacturing. A research trend seems to be emerging towards the use of human antibody formats as well as camelid heavy-domain antibody fragments due to their compatibility with the human immune system, beneficial therapeutic properties, and the ability to manufacture these molecules cost-effectively.
Pais:Kérwá
Institution:Universidad de Costa Rica
Repositorio:Kérwá
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/76544
Accés en línia:https://www.sciencedirect.com/science/article/pii/S0041010118301144?via%3Dihub
https://hdl.handle.net/10669/76544
Paraula clau:Antivenom
Venom
Recombinant antivenom
Antibodies
Snakebite
Scorpion sting
Spider bite
Animal envenoming
Pharmacokinetics
Pharmacodynamics
Immunogenicity
Venom neutralization
Antibody expression
Antivenom design
Adverse reactions
Neglected tropical diseases
Biotechnology
615.946 Venenos animales